abstract：:Ascites tumor cells (2 X 10(6] of a DMBA-induced rat mammary adenocarcinoma (HH9-cl 14) were injected s.c. into tumor-free syngeneic female rats and produced a continuously growing solid tumor in all animals of this group. Inoculation of 2 X 10(7) cells induced a first brief period of tumor growth, followed by complet...

journal_title：Journal of cancer research and clinical oncology

authors： Vollmer E,Shimamoto F,Krieg V,Grundmann E

更新日期：1986-01-01 00:00:00

abstract：:The effect of a single blood transfusion on the formation and outgrowth of experimental lung metastases was assessed in two tumor models in rats. The transfusions were given either 1 week before (day -7) or 1 week after (day +7) tumor cell inoculation. The first approach was performed to investigate the effect of tran...

journal_title：Journal of cancer research and clinical oncology

authors： Marquet RL,de Bruin RW,Dallinga RJ,Singh SK,Jeekel J

更新日期：1986-01-01 00:00:00

abstract：:A total of 45 cases of bone tumors and tumor-like lesions were studied in order to determine the expression of an HLA-DR antigen by the monoclonal antibody 910-D-7, and its possible correlation with histology, using the indirect immunoperoxidase method on frozen sections. The pattern of antigen expression was nearly c...

journal_title：Journal of cancer research and clinical oncology

authors： Petzsch M,Vassallo J,Roessner A,Zwadlo G,Sorg C,Vollmer E,Grundmann E

更新日期：1986-01-01 00:00:00

abstract：:The ileal sarcomas induced in rats given diet containing bracken fern were examined microscopically and electron microscopically. These ileal sarcomas, which were induced at high incidence (80%-44%), have previously been identified as spindle cell fibrosarcomas. However, studies showed that they should be diagnosed as...

journal_title：Journal of cancer research and clinical oncology

authors： Ogino H,Fujimoto M,Hirono I

更新日期：1986-01-01 00:00:00

abstract：:Some unsolved problems in DNA alkylation by N-nitroso compounds are discussed in this overview. Does O6 alkylation of guanine represent the initiating event exclusively or are O4 alkylation of thymidine and phosphate triester formation also involved in the initiating process? Does the formation of rearranged DNA alkyl...

journal_title：Journal of cancer research and clinical oncology

authors： Wiessler M

更新日期：1986-01-01 00:00:00

abstract：:To study whether fluorescent lighting at work might increase carcinogenesis, hairless mice were exposed to a bank of six 36 W standard fluorescent lamps (neutral-white) every workday for 8 h at an illuminance level of 1,000 lx. For comparison, other mice were exposed to UVB radiation or to simulated solar radiation. I...

journal_title：Journal of cancer research and clinical oncology

authors： Wiskemann A,Sturm E,Klehr NW

更新日期：1986-01-01 00:00:00

abstract：:The effect of beta-cyclodextrin-benzaldehyde (CDBA) on experimental pulmonary metastasis in C3H/He mice was examined. In an in vitro assay, the growth of RCT(+) cells was inhibited by 1200 micrograms/ml CDBA using unrenewed media, and by 600 micrograms/ml CDBA in that using daily renewed media. When mice were treated ...

journal_title：Journal of cancer research and clinical oncology

authors： Ochiai H,Niwayama S,Masuyama K

更新日期：1986-01-01 00:00:00

abstract：:Preoperative cytologic examinations were performed on bronchial material from 92 patients with postsurgical (pathologic) stage I (American Joint Committee) adenocarcinoma of the lung. All patients were followed up for at least 5 years or until death; thus, cases of adenocarcinoma metastatic to the lungs were virtually...

journal_title：Journal of cancer research and clinical oncology

authors： Bjornsson J,Goellner JR,Williams DE,Scheiber MV

更新日期：1986-01-01 00:00:00

abstract：:Although the biological action of phthalates has been widely discussed there is little information on early cellular changes indicative for toxic or carcinogenic effects. To study subtle alterations in the cell morphology, we have by means of image processing evaluated the nuclei of hamster hepatocytes after treatment...

journal_title：Journal of cancer research and clinical oncology

authors： Komitowski D,Schmezer P,Schmitt B,Ehemann V,Muto S

更新日期：1986-01-01 00:00:00

abstract：:1,1,2-Triphenylbut-1-enes substituted with 3- or 4-acetoxy (OAc) groups on one, two, or three phenyl rings were tested for their estrogen receptor affinities, their estrogenic and antiestrogenic properties in the immature mouse, and their effect on the growth of the hormone-dependent MXT mammary tumor of the mouse. Th...

journal_title：Journal of cancer research and clinical oncology

authors： Schneider MR

更新日期：1986-01-01 00:00:00

abstract：:The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined po...

journal_title：Journal of cancer research and clinical oncology

authors： Hemminki K,Försti A,Mustonen R,Savela K

更新日期：1986-01-01 00:00:00

abstract：:Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-...

journal_title：Journal of cancer research and clinical oncology

authors： Amberger H

更新日期：1986-01-01 00:00:00

abstract：:Radiation chimeras with trisomy 19 hematopoietic cells were constructed to test the sensitivity of the trisomic hematopoietic system to infection with Rauscher leukemia virus: Hematopoietic cells from livers of trisomic fetuses were rescued by transplantation into lethally irradiated adult mice. These Ts 19 radiation ...

journal_title：Journal of cancer research and clinical oncology

authors： Herbst EW,Gropp A,Pluznik DH

更新日期：1985-01-01 00:00:00

abstract：:Methods have been developed in an in vitro system (1) of assessing the number of disseminated tumor cells in peripheral blood and (2) of enriching tumor cells from peripheral blood samples for further characterization. Cells from three human carcinoma lines (E 14, ChaGo, and LEDWiDr) were mixed with leukocytes from no...

journal_title：Journal of cancer research and clinical oncology

authors： Schwartz R,Walk A,Toomes H,Schirrmacher V

更新日期：1985-01-01 00:00:00

abstract：:Human ovarian cancer cells from ten patients were cultured in the agar double layer assay as described by Hamburger and Salmon and in a methylcellulose monolayer system. The assays were compared under the same experimental conditions. The rate of positives (defined as greater than 30 colonies/dish) was 75% in the meth...

journal_title：Journal of cancer research and clinical oncology

authors： Runge HM,Neumann HA,Bücke W,Pfleiderer A

更新日期：1985-01-01 00:00:00

abstract：:In view of the great variation in the size of epithelial cell nuclei in benign changes in the mammary gland, the cytologist is often faced with diagnostic difficulties. Clear differences in the size of the nuclei in aspiration biopsies from the mammary glands of pregnant women and those from the mammary glands of post...

journal_title：Journal of cancer research and clinical oncology

authors： Schöndorf H,Naujoks H

更新日期：1985-01-01 00:00:00

abstract：:Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in ten primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carcinomas with trabecular and tubula...

journal_title：Journal of cancer research and clinical oncology

authors： Szendröi M,Lapis K

更新日期：1985-01-01 00:00:00

abstract：:Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic ...

journal_title：Journal of cancer research and clinical oncology

authors： Chitnis MP,Menon RS,Basrur VS,Adwankar MK,Satyamoorthy K

更新日期：1985-01-01 00:00:00

abstract：:Three oxygenated propylnitrosomethylamines were administered to female Syrian hamsters at doses similar to those which had induced high incidences of esophageal neoplasms in rats. Nitrosomethyl-2-oxopropylamine (NMOP) given at the rate of 2 mg/animal/week, whether as one application of 2 mg or two applications of 1 mg...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Kovatch RM,Knutsen GL

更新日期：1985-01-01 00:00:00

abstract：:In supporting the human-tumor cloning effort of the Southwest Oncology Group, we conducted an independent retrospective study to evaluate the clinical correlations of the soft-agar colony-forming assay developed by Hamburger and Salmon (1977). This study was made with the cooperation of 76 clinicians and 11 hospitals ...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Morgan LR,Schneider C,Blank H,Fan S

更新日期：1985-01-01 00:00:00

abstract：:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle chan...

journal_title：Journal of cancer research and clinical oncology

authors： Lindemann H

更新日期：1985-01-01 00:00:00

abstract：:A cohort of 5,477 male Japanese physicians was studied to examine the relationship between smoking habits and mortalities from cancer, coronary heart disease (CHD) and stroke over 12.7 years. The logistic regression analysis based on proportional hazard models was used for statistical assessment. The risks of both lun...

journal_title：Journal of cancer research and clinical oncology

authors： Kono S,Ikeda M,Tokudome S,Nishizumi M,Kuratsune M

更新日期：1985-01-01 00:00:00

abstract：:Phenotypically altered, preneoplastic cell populations were detected by micromorphological and cytochemical methods in a number of tissues treated with various chemical carcinogens. Further cellular analysis of carcinogenesis has shown that different cellular phenotypes follow each other during tumor development. Thus...

journal_title：Journal of cancer research and clinical oncology

authors： Bannasch P

更新日期：1984-01-01 00:00:00

abstract：:A dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks. BBN was given in four different concentrations, 50, 10, 5, and 1 ppm, to groups of 30 rats. The hi...

journal_title：Journal of cancer research and clinical oncology

authors： Ito N,Shirai T,Fukushima S,Hirose M

更新日期：1984-01-01 00:00:00

abstract：:The objective of this study was to compare urinary metabolism of parent 3,3-dimethyl-1-phenyltriazene with that of its ring-substituted 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene congeners, in an attempt to evaluate the molecular requirements for systemic carcinogenic ac...

journal_title：Journal of cancer research and clinical oncology

authors： Kolar GF,Habs M

更新日期：1984-01-01 00:00:00

abstract：:The concentration of estrogen receptor protein (ER) in 113 primary or metastatic breast cancers was studied. ER was found to be correlated with the age of the patient. The ER values were generally lower in premenopausal patients (5.6 fmol/mg cytosol protein) than in postmenopausal patients (32.8 fmol/mg cytosol protei...

journal_title：Journal of cancer research and clinical oncology

authors： Johansson R,Vanharanta R,Söderholm J

更新日期：1984-01-01 00:00:00

abstract：:Stereological point-counting methods were used to determine the volumetric alterations in collagen from the lamina propria immediately beneath the epithelial-connective tissue junction in hamster check-pouch mucosa treated with the chemical carcinogen DMBA. In addition, a non-neoplastic inflammatory control was evalua...

journal_title：Journal of cancer research and clinical oncology

authors： Tarpey SG,White FH

更新日期：1984-01-01 00:00:00

abstract：:We performed intraoperative peritoneal cytology in 171 gastric cancer patients undergoing curative surgery. Intraperitoneal free cancer cells were demonstrated in almost all patients in whom the area of serosal cancer invasion exceeded 15-20 cm2. In patients with both serosal cancer invasion and free cancer cells the ...

journal_title：Journal of cancer research and clinical oncology

authors： Koga S,Kaibara N,Iitsuka Y,Kudo H,Kimura A,Hiraoka H

更新日期：1984-01-01 00:00:00

abstract：:The role of L-tyrosine, L-phenylalanine, L-dihydroxyphenylalanine (dopa) and L-tryptophan in melanin biosynthesis in melanotic hamster melanoma IC-Sofia was investigated with the aid of 14C-aminoacids. Tyrosine and phenylalanine were found to be the main melanin precursors: about 64.5% of total melanin labeling was du...

journal_title：Journal of cancer research and clinical oncology

authors： Blagoeva PM

更新日期：1984-01-01 00:00:00

abstract：:In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no d...

journal_title：Journal of cancer research and clinical oncology

authors： Heim ME,Swoboda M,Pahlke W,Edler L,Bicker U

更新日期：1984-01-01 00:00:00

abstract：:As currently recognized, the essential aspects of ovarian carcinoma surgery are: (1) the search for occult metastases in tumors located in the lower pelvis, (2) the maximum tumor removal ("tumor-reductive surgery") in advanced ovarian carcinoma and (3) the exploratory laparotomy to confirm a complete clinical remissio...

journal_title：Journal of cancer research and clinical oncology

authors： Almendral AC

更新日期：1984-01-01 00:00:00

abstract：:Seventy-three evaluable patients with advanced measurable solid tumors were given cisdichlorodiammineplatinum (II) (DDP) at a dose of 20 mg/M2 IV for 1-5 days every 3 weeks, and 19 patients who failed on this low dose DDP protocol received a single high dose of 100 mg/M2 IV once every 3 weeks. Forty-six patients had r...

journal_title：Journal of cancer research and clinical oncology

authors： Schilcher RB,Wessels M,Niederle N,Seeber S,Schmidt CG

更新日期：1984-01-01 00:00:00

abstract：:Soft-agar clonogenicity of L1210 mouse leukemia cells and of xenografts of a human melanoma and a carcinoma of the cervix was studied sectionally by the sizes of the colonies grown under hypoxic gradients and aerobic condition. Soft-agar plating efficiency was increased in cultured L1210 cells with decreasing oxygen c...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Fan S,Morgan LR

更新日期：1984-01-01 00:00:00

abstract：:Butylnitrosourea (BNU) was used to induce thymic lymphomas in BDF1 mice. During and after the 12-week BNU exposure the spontaneous NK cell activity against YAC-1 cells and that arising 4 days after stimulation with Corynebacterium parvum (CP) were measured, as were the mitogen responses of splenic T and B cells. In ad...

journal_title：Journal of cancer research and clinical oncology

authors： Seidel HJ,Stolz W

更新日期：1984-01-01 00:00:00

abstract：:This study compares the level of DNA-DNA interstrand crosslinking in murine bone marrow with the decrease in mean number of blood progenitor cells in mice treated with chloroethylnitrosoureas. Male C57BL6 X C3HF1 mice were treated with single IP injections of 1-(2-chloroethyl)-1-nitroso-3-(methylene-carboxamido)-urea ...

journal_title：Journal of cancer research and clinical oncology

authors： Bedford P,Berger MR,Eisenbrand G,Schmähl D

更新日期：1984-01-01 00:00:00

abstract：:An in vitro double-labeling technique for determination of kinetic growth parameters was tested; 13 renal sarcomas of rats were incubated after excision under standardized conditions with 14C- and 3H-thymidine successively. Another ten tumors were evaluated after in vivo double injection of 14C and 3H-thymidine into s...

journal_title：Journal of cancer research and clinical oncology

authors： Lang W,Kienzle S,Georgii A

更新日期：1983-01-01 00:00:00

abstract：:The histologic grade of regression of 50 osteosarcomas after polychemotherapy - according to the protocol study, COSS 80 - was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- and CPL-treated patie...

journal_title：Journal of cancer research and clinical oncology

authors： Salzer-Kuntschik M,Delling G,Beron G,Sigmund R

更新日期：1983-01-01 00:00:00

abstract：:This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the perc...

journal_title：Journal of cancer research and clinical oncology

authors： Heine UI,Krueger GR,Karpinski A,Munoz E,Krueger MB

更新日期：1983-01-01 00:00:00

abstract：:Hybridoma clones were produced by fusion of splenocytes from glioma-immunized hosts and the X63-Ag8.653 mouse myeloma line and Y3-Ag.1.2.3. rat myeloma line. Oncornavirus particles were found in all clones descending from the mouse myeloma line. No virus particles could be found in either the spleens of immunized Balb...

journal_title：Journal of cancer research and clinical oncology

authors： Stavrou D,Bilzer T,Tsangaris T,Dürr E,Steinecke M,Anzil AP

更新日期：1983-01-01 00:00:00

abstract：:After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell ca...

journal_title：Journal of cancer research and clinical oncology

authors： Eichler G,Habs M,Schmähl D

更新日期：1983-01-01 00:00:00